Due to known sanitary restrictions, the 2021 Congress of the Italian Society of Biochemistry and Molecular Biology (SIB) will take place as a virtual edition. We are pleased to announce the new format and a series of talks and topics that for two days will cover many dynamic aspects of our biochemical community. We are confident that through the planned series of invited and Keynote lectures, six Sessions, and a roundtable on education and mentoring, the SIB community will find an opportunity to exchange openly new ideas and opportunities. Please have a look at the Program and at the means of participation that include new ways for presenting results (short videos and poster discussion virtual rooms). We look forward to a broad participation (notice that young SIB members have access at no charge), which is also open to FEBS members from all European countries.